Semaglutide vs Tirzepatide vs Retatrutide: Research Comparison

Research-use notice: This page compares sequences, receptor classes, and catalog records. It is not medical or veterinary advice, and it does not rank materials for personal use. BlueNex Labs materials are research-use only. Research-use-only labeling is not a Health Canada authorization and it does not create a Drug Identification Number.

Semaglutide, tirzepatide, and retatrutide are long, modified peptides that purchasing offices often file as one incretin group. The group is a shelf. The receptor sets in the discovery papers are not the same, the sequences are not the same, and the catalog fills are not the same. This page compares ligand class, chain features, milligram listings, and which lots have a Certificate of Analysis. It does not restate sponsor endpoints, and it does not describe these solids as medicines. The class note is incretin receptor ligands. The 2026 map is GLP-1 peptide research in 2026.

Three ligand classes

Lau and colleagues, in the Journal of Medicinal Chemistry in 2015, described semaglutide as a GLP-1 analogue built on the GLP-1(7-37) frame, with aminoisobutyric acid at position 8, arginine at position 34, and a fatty-diacid derivative on lysine 26 (PMID 26308095). The receptor named in that chemistry is the GLP-1 receptor. The glossary entry is GLP-1 receptor. This page cites the substitutions and the receptor. It does not copy exposure intervals or animal readouts from the paper onto a vial.

Coskun and colleagues, in Molecular Metabolism in 2018, described tirzepatide (LY3298176) as a dual ligand at the GIP receptor and the GLP-1 receptor (DOI 10.1016/j.molmet.2018.09.009). The chain is a 39-residue acylated peptide, not the semaglutide frame with a new label. A second Coskun paper, in Cell Metabolism in 2022, described retatrutide (LY3437943) as a ligand at the glucagon receptor, the GIP receptor, and the GLP-1 receptor (DOI 10.1016/j.cmet.2022.07.013). Published ligand records describe that molecule as a 39-residue acylated peptide as well. Shared length with tirzepatide is not shared sequence. The third receptor, glucagon, is the class mark that separates retatrutide from the dual ligand in those papers.

Those sentences are how the papers name the receptors. They are not measurements of a BlueNex Labs lot. Public trial literature for retatrutide is a different object from a lyophilized catalog vial. Read the trial literature note and the FDA status note for the public record. Do not paste a registry result into a certificate cell. An investigational programme is not a Health Canada authorization.

Fills, caps, and the amylin neighbour

Each name is one shop path with more than one research fill. A 10 mg chromatogram does not document a 20 mg or 30 mg vial, even when the common name matches. Retatrutide's library rows distinguish blue, purple, and pink caps for the 10 mg, 20 mg, and 30 mg fills. Tirzepatide's rows distinguish the 10 mg and 30 mg fills. Match cap colour when the library prints it. Semaglutide's 10 mg and 20 mg listings had no library anchor on the September 20, 2026 review. Leave that cell blank rather than borrowing a tirzepatide PDF because both papers mention the GLP-1 receptor.

Cagrilintide 5 mg sits on the same metabolic category and is not a fourth column in this table. It is an amylin analogue. The class term is incretin receptor ligand, which on this site also points at that neighbour so purchasing offices do not file it as a GLP-1 sequence. A semaglutide line in a parcel does not document cagrilintide.

What the study file should hold

Write the receptor set from the paper you actually opened, then the shop slug, then the milligram fill, then the lot or the statement that no lot is published. How to read a peptide COA applies to the rows that exist: area percent under the stated method, mass against the modified sequence, endotoxin only when the file includes it. A fatty-diacid modification is part of the mass. Do not compare an observed mass with the unmodified parent peptide and call a mismatch a failure of the lot, or the reverse. The modification has to be the one named for that SKU.

Shipping is inside Canada only, after Interac e-Transfer, on Canada Post Xpresspost. The desk note is Canada laboratory procurement. This page is not a city doorway. Sold-out sizes stay listed and cannot be added to the cart. Research-use only. Not for human or veterinary use.