Sermorelin vs Tesamorelin: Research Comparison

Research-use notice: This page compares sequences, receptor classes, and catalog records. It is not medical or veterinary advice, and it does not rank materials for personal use. BlueNex Labs materials are research-use only. Research-use-only labeling is not a Health Canada authorization and it does not create a Drug Identification Number.

Sermorelin and tesamorelin are both synthetic analogues discussed at the GHRH receptor, and both live listings are 10 mg. The shared receptor and the shared milligram are why purchasing lines swap them. The chains are not the same length, and one of them carries an N-terminal modification the other does not. This page is that structural and catalog difference. The class note is GHRH analogs. The glossary entry is GHRH. Neither page is a protocol, and neither page ranks the analogues.

Where the sequences split

Human growth hormone-releasing hormone was reported as a 44-residue peptide. Guillemin and colleagues described that hormone from a pancreatic tumour extract in Science in 1982 (PMID 6812220). The 1-29 region is the N-terminal portion papers discuss as sufficient for GHRH-receptor work. Sermorelin is that fragment as a C-terminal amide: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2. Twenty-nine residues, no fatty acyl tail, and an amide at the C terminus are the identity marks. A calculated mass for those 29 residues will not match a 44-residue analogue.

Tesamorelin keeps the full 44-residue human sequence and adds chemistry at the N terminus. Chemical records describe it as N-[(3E)-hex-3-enoyl] attached to tyrosine-1 of GHRH(1-44) amide, also called TH9507. Ferdinandi and colleagues discussed that analogue in Basic and Clinical Pharmacology and Toxicology in 2007 (PMID 17214611). This page uses the paper for the structure: a trans-3-hexenoyl group on the 44-residue amide. It does not restate the animal measurements in that paper, and it does not turn those measurements into a catalog claim. The extra fifteen residues are Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu, and the hexenoyl group shifts the mass again. Length alone is enough to keep the certificates apart.

Same receptor class, different lots

Both names are filed on the GHRH-receptor side of the secretagogue shelf, not on GHSR-1a. Ipamorelin is the GHSR ligand. CJC-1295 without DAC is a third GHRH-analogue backbone, sold only inside the paired fill, and compared with ipamorelin on a separate page. A sermorelin report does not document that pair, and a tesamorelin report does not document sermorelin. The category hub lists all four live secretagogue SKUs so the grid is not mistaken for one molecule.

Some lots of tesamorelin are discussed in handling papers because the wetted solid can self-associate and gel. That note is why tesamorelin can gel. It is physical chemistry of the sequence after wetting. It is not a reconstitution protocol, and it does not apply the same sentence to sermorelin unless the lot in front of you shows the same behaviour. Kisspeptin appears in that handling note because of its own gelation chemistry. Kisspeptin is not a GHRH analogue and it is not part of this comparison.

Why 10 mg is not an identity

Both product records list a 10 mg variant. Equal fill mass is a catalog coincidence. It is not evidence that the powders match. The tesamorelin anchor on the September 20, 2026 review includes mass and endotoxin links for that lot. Sermorelin has no anchor on that review. Do not copy the tesamorelin area percent into a sermorelin row to fill the gap. How to read a peptide COA separates the area percent from the mass. The mass has to fit the sequence you wrote down, including the hexenoyl group when the name is tesamorelin and excluding it when the name is sermorelin.

IGF-1 LR3, follistatin-344, and AOD-9604 remain research notes without shop URLs. A GHRH-analogue certificate does not describe them. If a secondary source prints those names beside sermorelin, return to the research note and do not invent a cart line.

Fulfilment

Payment is Interac e-Transfer. Shipping is Canada Post Xpresspost inside Canada. Details sit on the procurement guide. Store the sealed lyophilized vial the day it arrives. Research-use only. Not for human or veterinary use.