Is MOTS-c the same molecule as SS-31?

No. MOTS-c is the 16-residue mitochondrial ORF peptide. SS-31 is a synthetic mitochondria-targeted tetrapeptide. Each has its own shop URL and its own lot record.

Glossary · 2026-09-24

Scientific lead: Alice Kay, Ph.D.

MOTS-c, mitochondrial ORF peptide

MOTS-c means mitochondrial open reading frame of the 12S rRNA type-c. Lee and colleagues reported a 16-residue peptide from a short open reading frame in mitochondrial 12S rRNA (Cell Metabolism, 2015, PMID 25738459). The paper discusses cellular-energy models, including the folate cycle and AMPK, in the systems the authors measured. Those findings are not a specification on a catalog label, and this page does not restate the paper's animal endpoints as a product claim.

The buy-intent URL is MOTS-c 10 mg. The compound guide is What is MOTS-c?. The class page is mitochondrial peptides. SS-31 is a different, shorter, synthetic tetrapeptide.

Frequently asked questions

Is MOTS-c the same molecule as SS-31?: No. MOTS-c is the 16-residue mitochondrial ORF peptide. SS-31 is a synthetic mitochondria-targeted tetrapeptide. Each has its own shop URL and its own lot record.

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