Glossary · 2026-09-24
By Alice Kay · Last reviewed 24 Sep 2026
MOTS-c, mitochondrial ORF peptide
Research-use notice: This article summarizes published scientific literature for educational purposes. It is not medical advice and does not provide dosing, administration or human-use information. Findings described in the literature do not apply to any BlueNex Labs product, which is supplied only for in-vitro laboratory research and not for human or animal use.
MOTS-c means mitochondrial open reading frame of the 12S rRNA type-c. Lee and colleagues reported a 16-residue peptide from a short open reading frame in mitochondrial 12S rRNA (Cell Metabolism, 2015, PMID 25738459). The paper discusses cellular-energy models, including the folate cycle and AMPK, in the systems the authors measured. Those findings are not a specification on a catalogue label, and this page does not restate the paper's animal endpoints as a product claim.
For the buy-intent URLs, see MOTS-c 10 mg and MOTS-c 40 mg. For the compound guide, see What is MOTS-c?. For the class page, see mitochondrial peptides. SS-31 is a different, shorter, synthetic tetrapeptide.
Frequently asked questions
- Is MOTS-c the same molecule as SS-31?
- No. MOTS-c is the 16-residue mitochondrial ORF peptide. SS-31 is a synthetic mitochondria-targeted tetrapeptide. Each has its own shop URL and its own lot record.
Research use only. BlueNex Labs does not provide medical or veterinary advice. Confirm your institution’s policies before purchase. How a comparison or class note is checked sits on documentation standards. Articles are written and reviewed by Alice Kay, Ph.D.