MOTS-c 16-residue laboratory note

Research-use notice: This article is laboratory and educational information only. It is not medical or legal advice, and it does not include how-to-use instructions. BlueNex Labs materials are research use only and are not intended for human or veterinary use. Research-use-only labelling is not a Health Canada authorization.

Publication status: Prepared for the BlueNex Labs Research Knowledge Centre. Literature and library notes checked September 24, 2026. Primary papers and the public COA library can change; verify the lot report in hand before an assay.

MOTS-c, on this catalogue, is a lyophilized 16-residue peptide sold for laboratory work in two fills. For the shop URLs, see MOTS-c 10 mg and MOTS-c 40 mg. This page is the sequence and lot note. For the shorter class overview, see What is MOTS-c?. Neither page is a method. Price and stock stay on each listing.

Sequence and where the open reading frame sits

Lee and colleagues, in Cell Metabolism in 2015, reported a short open reading frame in the mitochondrial 12S rRNA that encodes a 16-amino-acid peptide, and they named it MOTS-c, mitochondrial open reading frame of the 12S rRNA-c (PMID 25738459). The sequence recorded on this site's MOTS-c versus SS-31 comparison is Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg, one-letter code MRWQEMGYIFYPRKLR. Sixteen residues, an N-terminal methionine, and no disulfide in that written string are the identity marks this note uses. For the glossary lines, see MOTS-c, sequence, N-terminus, and linear peptide.

UniProt accession A0A0C5B5G6 lists that same 16-residue chain and a calculated mass of 2175 for the unmodified sequence, and it cites the 2015 paper (UniProt A0A0C5B5G6). That database mass is not the lot result. Copy the mass and the species from the file in hand. If they do not fit the 16-residue chain, stop and hold the vial. The 2015 paper also states that this frame is translated with the standard genetic code in the cytoplasm, because the mitochondrial code yields tandem start and stop codons. That is a biosynthetic description. It is not a preparation method.

What the 2015 cell model is for

Lee and colleagues describe cellular actions on the folate cycle and on de novo purine biosynthesis, with AMPK activation in the systems they measured. This note cites that class of model. It does not restate animal endpoints, and it does not turn a figure into a specification on either cake. For the mechanism page, see mitochondrial peptides. For the class glossary line, see mitochondrial peptide.

SS-31 is a synthetic tetrapeptide. Length alone keeps the certificates apart. The catalogue nucleoside AICAR has its own laboratory note. NAD+ has its own note. Humanin is named in the 2015 paper and is not a shop URL here. None of those files document this 16-residue vial.

Two labelled amounts, two files

The catalogue lists a 10 mg fill and a 40 mg fill. The sequence claim is the same. The labelled amount is not. A 10 mg report does not document a 40 mg vial.

Analytical documentation

A catalogue name is not an identity test for MOTS-c. Open how to read a peptide Certificate of Analysis and the purity-versus-mass note. The short version of the same check is the COA verification FAQ. Copy the task identifier from the Janoshik URL on verify.janoshik.com or janoshik.com, the sample name, the date, the mass, the purity figure and its method, and any endotoxin number with its unit. A photograph of a report is not the report. Cap colour and the labelled milligram size are lot-specific. A file for a different size does not document this container.

Chromatographic area percent and mass identity answer different questions. Read chromatogram, mass spectrum, purity versus identity, and molecular weight before you file one number as both answers. Salt form, when the PDF names trifluoroacetate or acetate, is a third line. For the glossary entries, see TFA salt and acetate salt. This catalogue does not publish a house factor that converts a salt weight into a free-base figure. If the report is silent, leave the salt line blank. Net peptide content is recorded only when the PDF states it.

The 10 mg library row is MOTS-c 10 mg in the certificates library. The 40 mg library row is MOTS-c 40 mg in the certificates library. Match the sample name to the vial in hand. Cap colour is lot-specific. A photograph of either report is not the report.

The receiving log for this material is ordinary and short. Write the product name, the labelled amount, the cap colour if one is printed, the lot number or batch code, the receipt date, the storage location, the report URL, and whether the sample name matched the container in hand. Quarantine the container when the seal is broken, the solid looks wet, the label does not match the packing list, or the report link will not open. The Burnaby desk can look up an order number. It cannot reconstruct identity from a container that has already been relabelled by hand.

Handling and Canada fulfilment

The solid is stored sealed because residual water can cleave peptide bonds and can collapse a cake. For the format primer, see lyophilized research peptides. Open the parcel the day it arrives. Do not leave it in a vehicle, an outdoor box, or on a loading dock. Move the closed vial into controlled storage and follow the temperature on the product note. A cake that looks different after a cold Canada Post parcel is not an identity test. Do not heat a very cold vial. For the receiving note, see peptide storage for Canadian laboratories. This page does not list a diluent volume. If a laboratory SOP calls for a separate diluent, bacteriostatic water and reconstitution diluent are glossary entries for that reagent, not a volume for this vial.

Paid orders ship on Canada Post Xpresspost inside Canada after Interac e-Transfer. The desk is 4309 Canada Way, Burnaby, BC V5G 1J3. The label sender is a Port Moody, BC PO Box for the carrier account. Put the order number in the Interac message field so the payment can be matched to the emailed invoice. A tracking number is emailed when the label is created. Our parcels are not picked up on weekends or statutory holidays, so a Friday payment can sit until the next operating day. Estimates are not guarantees. Those facts are restated on the shipping FAQ and the payment FAQ. For the procurement note, see Canada laboratory procurement. The shop URL is MOTS-c 10 mg.

A research-use-only container is not a clinical-trial drug product and it does not carry a Drug Identification Number. The distinction is on the catalogue-versus-trial FAQ. What the research-use-only phrase does and does not do, including the point that the phrase is not by itself a Health Canada authorization, is on the research-use-only FAQ. This page is not legal advice. Domestic Xpresspost keeps the parcel on a Canadian carrier. It does not remove research-use-only limits, and it does not make a catalogue solid into an authorized drug.

SS-31, NAD+, and AICAR keep their own library rows. Those PDFs do not document MOTS-c, even when the containers arrive in one parcel. The class overview remains the place for Humanin and the wider mitochondrial-peptide reading list. This page stays on the 16-residue string and the two fills.

For the category index that currently lists this material, see the mitochondrial category. The category also lists SS-31, NAD+, AICAR, and other reagents. The menu is a purchasing route. It does not make those materials the same sequence as MOTS-c.

Frequently asked questions

What sequence does this MOTS-c note use?

The 16-residue chain MRWQEMGYIFYPRKLR, the sequence Lee and colleagues reported in 2015 for the peptide encoded in mitochondrial 12S rRNA. The lot file still has to match that mass. The web page is not the spectrum.

Do the 10 mg and 40 mg MOTS-c vials share one Certificate of Analysis?

No. Each fill has its own shop URL and library row. A 10 mg purity file does not document a 40 mg vial. The 40 mg row publishes its own purity COA.

Is MOTS-c the same sequence as SS-31?

No. MOTS-c is the 16-residue mitochondrial open-reading-frame peptide. SS-31 is a synthetic tetrapeptide. The certificates are not interchangeable.

Is the catalogue MOTS-c vial a clinical-trial drug product?

No. The 10 mg and 40 mg fills are lyophilized research solids. An investigational program is a different object. Research-use-only wording is not a Health Canada authorization.