Glossary · 2026-09-24
Scientific lead: Alice Kay, Ph.D.
Peptide bond, laboratory definition
A peptide bond is the amide linkage formed when the carboxyl group of one amino acid joins the amino group of the next, releasing water. A peptide is a chain of those bonds. Proteins are longer chains. The research solids in this catalog are the short end of that range, often about 2 to 50 residues, supplied lyophilized so the chain stays dry until the laboratory opens it.
The bond is also why moisture matters. Hydrolysis cleaves amide bonds. That is a storage fact, not a protocol. See how peptides are discussed as laboratory ligands and peptide structure and stability.
Frequently asked questions
- Is a peptide bond the same as a disulfide bond?
- No. The peptide bond is the backbone amide. A disulfide is a side-chain link between cysteines. A sequence can have both. The Certificate of Analysis mass reflects the form the report measured.
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