GHRH analogs in laboratory models

Research-use notice: This page is a laboratory mechanism note. It is not medical or veterinary advice, and it does not include personal-use steps. BlueNex Labs materials are research-use only. Research-use-only labeling is not a Health Canada authorization and it does not create a Drug Identification Number.

Growth hormone-releasing hormone (GHRH) is the hypothalamic reference ligand for the GHRH receptor, a G protein-coupled receptor studied in somatotroph and pituitary-cell models. Analogues in this class are synthetic sequences discussed at that receptor. They are not ghrelin-receptor ligands. GHSR-1a is a different GPCR, and the mechanism note for it is GHSR ligands. This page keeps the two receptors apart and then maps only the GHRH-analogue names that BlueNex Labs actually sells.

What the receptor literature is doing

Laboratory papers in this area ask whether a modified GHRH fragment still binds the GHRH receptor, whether a second-messenger readout in cells that express that receptor changes when the sequence changes, and whether a chemical appendage changes how long the conjugate remains measurable in the model under study. Those are assay questions. A result inside one cell system stays inside that system. This catalog does not restate a paper as a label claim, and it does not copy concentrations from a methods section onto a purchasing form.

The plain-language class name on the shop is secretagogue. That word is a shelf, defined in the secretagogue glossary entry and on the secretagogue category hub. A shelf is not a sequence. Write the receptor and the SKU in the study file before you write a conclusion.

CJC-1295 without DAC is not the 2005 conjugate

Jetté and colleagues, in Endocrinology in 2005, identified CJC-1295 as a tetrasubstituted analogue of hGRF(1-29) carrying an N-epsilon-3-maleimidopropionamide derivative of lysine at the C terminus (DOI 10.1210/en.2004-1286). That maleimidopropionyl group is the drug affinity complex, or DAC. In their rat experiments the conjugate was discussed as binding albumin and as remaining detectable in plasma longer than unmodified hGRF(1-29). That pharmacokinetic description belongs to the conjugate they defined. It is not a specification for a vial that is labeled no DAC.

"No DAC" means the albumin-binding group is absent. The remaining backbone is still discussed as a GHRH-receptor analogue. It is not sermorelin, and it is not ipamorelin. BlueNex Labs does not list a CJC-only SKU. The live item is CJC-1295 (no DAC) / ipamorelin 5 mg/5 mg. A request for bare /shop/cjc-1295 redirects to that fill. The paired research guide is CJC-1295 and ipamorelin. Pairing the names on one label is convenient receiving. It does not merge two sequences into one molecular weight.

Ipamorelin in that vial is the pentapeptide assigned to GHSR-1a, not to the GHRH receptor. If a notebook says only "the blend," the file has not recorded which receptor each solid is for. The CJC-1295 (no DAC) and ipamorelin glossary entries are the short definitions. The ipamorelin 10 mg listing is a different lot from the 5 mg portion inside the pair.

Sermorelin and tesamorelin are separate analogues

Sermorelin is discussed in the laboratory literature as a GHRH(1-29) amide analogue: the N-terminal portion of GHRH that papers describe as sufficient for receptor work, amidated at the C terminus. The catalog URL is sermorelin 10 mg. It is not a nickname for CJC-1295. A certificate for the paired CJC fill does not document sermorelin, and a sermorelin report does not document tesamorelin.

Tesamorelin is a further synthetic GHRH analogue, sold here as tesamorelin 10 mg. It is not the same sequence as sermorelin and it is not the DAC conjugate. Some lots of tesamorelin, and some lots of kisspeptin, are discussed in handling papers because the wetted solid can self-associate and gel. That physical-chemistry note is why tesamorelin can gel. It is not a reconstitution protocol, and it does not move tesamorelin onto the ghrelin receptor.

Names that stay off the shop

Three neighboring strings are easy to paste into a secretagogue cart and should not be. IGF-1 LR3 is an insulin-like growth factor analogue used in IGF-1 receptor models. Follistatin-344 is discussed as an activin-binding isoform, not as a short GHRH fragment. AOD-9604 is an hGH-fragment research note. None of those guides has a /shop URL. A GHRH-analogue Certificate of Analysis does not describe them. If a secondary source prints those names beside ipamorelin, return to the guide and do not invent a cart line.

Lot match, then fulfilment

Identity for a GHRH analogue is still the observed mass versus the mass calculated from the stated sequence, plus the chromatographic area percent on the same file. Read how to read a peptide COA. The library anchor for the paired fill, when published, is certificates#cjc-1295-no-dac-ipamorelin-5mg-5mg. That PDF does not document ipamorelin 10 mg, sermorelin, or tesamorelin. Record the sample name before the material enters a study file.

Orders ship inside Canada after Interac e-Transfer, on Canada Post Xpresspost. The procurement note is Canada laboratory procurement. Solids arrive lyophilized. Move the sealed vial into controlled storage the same day. This page stops at the receptor class and the lot. It does not list solvent volumes. Legal category is a separate question: Are research peptides legal in Canada?. Research-use-only wording is not a Drug Identification Number.