NAD+ in energy-metabolism research

Publication status: Prepared for the BlueNex Labs Research Knowledge Centre. Literature and library notes checked September 25, 2026. Primary papers and the public COA library can change; verify the lot report in hand before an assay.

NAD+ is nicotinamide adenine dinucleotide in the oxidized form. It is a dinucleotide: nicotinamide, adenine, and two ribose phosphates. It is not a peptide, and it is not an amino-acid chain that a peptide chromatogram can identify. For the catalogue listings, see NAD+ 500 mg and NAD+ 1000 mg. This page separates the cofactor literature from consumer drip marketing. It is not a protocol, and it is not an intravenous product page.

Two jobs in the biochemistry, kept apart

In dehydrogenase reactions NAD+ accepts a hydride and becomes NADH. That pair moves reducing equivalents. In a second set of reactions, enzymes consume NAD+ as a substrate rather than regenerating it in the same cycle. Sirtuins and poly(ADP-ribose) polymerases are the families reviews name for that second job. Cantó, Menzies, and Auwerx summarized both roles, and the link to mitochondrial and nuclear energy status, in Cell Metabolism in 2015 (PMID 26118927). This note cites the review for the cofactor chemistry. It does not adopt the review's disease-management language, and it does not turn a lyophilized research solid into the interventions the review discusses.

A peptide Certificate of Analysis cannot answer either job. Area percent on a peptide method sees peptide bonds and aromatic residues under that method. NAD+ is a different molecule. Filing a MOTS-c or SS-31 PDF under the NAD+ name fails the sample-name check before the mass is even compared. For the glossary line, see NAD+. For the class term that NAD+ is not, see mitochondrial peptide.

Why the catalogue sits on the mitochondrial route

Energy-metabolism orders often place the cofactor beside mitochondrial peptides and small-molecule reagents. The mitochondrial category hub says so. MOTS-c is a 16-residue open-reading-frame peptide. SS-31 10 mg and SS-31 50 mg are the tetrapeptide fills. AICAR is a nucleoside used in AMPK papers. None of those is NAD+. The comparison MOTS-c versus SS-31 states the same boundary. For the class mechanism page, see mitochondrial peptides.

Two fills, two library rows

The 500 mg listing and the 1000 mg listing are separate products. On the September 20, 2026 review, the 500 mg silver cap is documented on the NAD+ 500 mg certificate and the 1000 mg gold cap on the NAD+ 1000 mg certificate. Each row has mass and endotoxin links of its own. A 500 mg file does not document a 1000 mg vial. Cap colour is a handling cue. The milligrams on the label still control if a later batch reuses a colour. How to read a peptide COA is written for peptides and still applies to the practical pass: sample name, task identifier, mass, and any endotoxin number with its unit. A photograph of a report is not the report.

Consumer headlines that describe drips, award-season media, or subjective energy are a different market. They are not Certificates of Analysis and they are not Health Canada authorizations. If a secondary article uses that framing, leave it in that article. This shop's intended use for the listing is laboratory work. Research-use-only labelling is not an authorization. Read Are research peptides legal in Canada?.

Receiving a cofactor parcel

NAD+ is not a peptide, so there is no peptide bond for water to cleave. A dry solid can still take up moisture. Leave the container sealed, open the parcel the day it arrives, and do not leave it in a vehicle or on a loading dock. Move it into controlled storage and follow the temperature on the product note. Do not heat a very cold container. The receiving note peptide storage for Canadian laboratories is the parcel practice, not a claim that NAD+ is a peptide. This page does not list a solvent volume.

Checkout is Interac e-Transfer. Parcels move on Canada Post Xpresspost inside Canada. The desk is in Burnaby. Labels use a Port Moody PO Box. For the operational page, see Canada laboratory procurement. Sold-out size is inventory. It does not change the cofactor, and it does not create a backorder.

What to write beside the vial

Write NAD+, the milligrams, the cap, the lot, the report URL, and the statement that the sample is a dinucleotide rather than a peptide. "Mitochondrial" alone fails that line. A study file that also holds MOTS-c needs a second row. Publishing rules for the library are on documentation standards. Articles are written and reviewed by Alice Kay, Ph.D.

What this note will not borrow from a peptide file

A peptide chromatogram looks for peptide bonds and aromatic residues under that method. NAD+ will not produce a meaningful area percent on that method, and a peptide mass will not confirm a dinucleotide. If a receiving template has columns for sequence, salt, and net peptide content, leave them blank or write "not a peptide" rather than forcing a residue string. The 500 mg silver-cap file and the 1000 mg gold-cap file stay on separate lines even when both arrived in one parcel. Cap colour is a cue. The labelled milligrams still control.

Secondary articles that describe drips, award-season media, or a subjective sense of energy are not citations for the lot. They are not Health Canada authorizations. Quote the Cantó review for the cofactor chemistry only. Do not import its disease-management sentences into a purchasing form, and do not describe the listing as an intravenous product because a headline used that frame. For the shop URLs, see NAD+ 500 mg and NAD+ 1000 mg. Price and stock stay on those pages. This article records the molecule class and the library split.

The desk is 4309 Canada Way, Burnaby, BC V5G 1J3. Labels use a Port Moody PO Box. Put the order number in the Interac message field so the desk can match the payment to the parcel. Those operational facts are the same for a cofactor as for a peptide. They do not make NAD+ a peptide, and they do not fill a blank analytical cell. If the size you need is sold out, the card stays visible and cannot be added to the cart. Email the desk rather than substituting a mitochondrial peptide for the cofactor.

Frequently asked questions

Is the NAD cofactor a peptide?

No. NAD+ is nicotinamide adenine dinucleotide, a dinucleotide redox cofactor. It is not a chain of amino acids. A peptide Certificate of Analysis does not document it.

Do the 500 mg and 1000 mg NAD fills share one report?

No. The 500 mg silver-cap row is on NAD+ 500 mg. The 1000 mg gold-cap row is on NAD+ 1000 mg. Match the labelled amount. A file for one size does not document the other.

Does this note describe an intravenous product?

No. Consumer drip marketing is a different market. This catalogue lists a research cofactor. The page does not give a preparation method.

How does a NAD order ship in Canada?

Interac e-Transfer, then Canada Post Xpresspost inside Canada. The desk is in Burnaby. The catalogue does not ship outside Canada.

Catalogue cross-reference

For the laboratory cofactor listings, see NAD+ 500 mg and NAD+ 1000 mg. Use the NAD+ 500 mg certificate row for the silver cap and the NAD+ 1000 mg certificate row for the gold cap. This is not a drip SKU.

Orders ship inside Canada only after Interac e-Transfer checkout. Sold-out SKUs remain listed and cannot be added to the cart. Match each vial to its own Certificate of Analysis when a lot is published. Research use only. Not for human or veterinary use. This page is not a protocol.