GHSR ligands in laboratory models

Research-use notice: This page is a laboratory mechanism note. It is not medical or veterinary advice, and it does not include personal-use steps. BlueNex Labs materials are research-use only. Research-use-only labeling is not a Health Canada authorization and it does not create a Drug Identification Number.

GHSR-1a is the growth hormone secretagogue receptor type 1a, the G protein-coupled receptor that binds ghrelin. Papers distinguish it from GHSR-1b, a truncated splice variant discussed as lacking the same signaling competence, and from the GHRH receptor. A ligand that is assigned to GHSR-1a is not a GHRH analogue. The class note for that other receptor is GHRH analogs. This page is only the ghrelin-receptor side of the secretagogue shelf.

Ipamorelin is the live ligand

Ipamorelin is the synthetic pentapeptide Aib-His-D-2-Nal-D-Phe-Lys-NH2. Raun and colleagues described it in 1998 as a growth hormone secretagogue that, in their pharmacological profiling, acted through a GHRP-like receptor rather than the GHRH receptor (PMID 9849822). The sequence lacks the central Ala-Trp dipeptide of an earlier GHRP series. Those are structural and receptor-assignment facts from that paper. The paper also reports cell and animal measurements. This catalog does not reprint those concentrations, and it does not turn a 1998 figure into a method for the vial on the bench.

The aminoisobutyric acid and the D-residues change the calculated mass relative to an all-proteinogenic pentapeptide of the same length. LC-MS is how a laboratory checks that the observed mass matches the stated sequence. The glossary entry is ipamorelin. The receptor entry is GHSR-1a.

Two shop URLs, two lots

Ipamorelin 10 mg is the single-peptide listing. CJC-1295 (no DAC) / ipamorelin 5 mg/5 mg is a convenience fill that also contains a GHRH-analogue backbone. The ipamorelin mass in the blend is not a documentation shortcut for the 10 mg vial, and the 10 mg certificate does not document the blend. When a Janoshik file is published, match the sample name and the milligram split to the glass in hand. The paired-topic guide is CJC-1295 and ipamorelin.

CJC-1295 without DAC remains a GHRH-receptor sequence even when it shares a vial with ipamorelin. Receiving staff should log two names, two masses, and one inventory SKU. Collapsing that line to "secretagogue" loses the receptor split that the category hub is written to preserve.

What GHSR assays report, and what they do not

Published GHSR work often measures competitive binding against a labeled ghrelin-receptor probe, or a calcium or inositol-phosphate readout in cells transfected with GHSR-1a. Those endpoints ask whether the peptide engages that receptor in that cell. They do not assign the peptide to the GHRH receptor, the melanocortin receptors, or the GLP-1 receptor. They also do not set a human exposure. BlueNex Labs does not provide personal-use steps, and this page does not rank ligands by a consumer outcome.

Earlier GHRPs such as GHRP-6 and GHRP-2 appear in the same 1998 comparison as historical controls inside that study. They are not catalog SKUs. Do not add them to a purchase order because a citation named them. If a method section calls for a GHRH analogue instead, leave this page and open sermorelin, tesamorelin, or the no-DAC portion of the paired fill, described on the GHRH analog note.

Keep the assay column matched to the receptor

GHSR-1a signaling papers usually follow a Gq-coupled path: a rise in inositol phosphates or intracellular calcium in cells that express the receptor. GHRH-receptor papers usually follow a Gs-coupled path and a cyclic AMP readout. The distinction is why a single "secretagogue assay" line in a notebook is too coarse. If the method says calcium, you are probably in GHSR territory. If the method says cyclic AMP at the GHRH receptor, you are probably looking at sermorelin, tesamorelin, or the no-DAC backbone. Write the readout next to the SKU so a later reader does not swap the PDFs.

The paired 5 mg/5 mg vial is the case that needs both columns. One inventory line, two receptors, two masses. The secretagogue word can stay on the purchasing category. It should not be the only word on the analytical worksheet. When a lot report is missing, record the absence. Do not borrow the other peptide's area percent to fill the gap.

Documentation and Canada fulfilment

A Certificate of Analysis for a GHSR ligand should show identity and purity for the pentapeptide, not for the GHRH analogue that sometimes travels with it. How to read a peptide COA separates the area percent from the mass. Endotoxin, when the library row includes it, is a third line. An absent line means the test was not published. It does not mean a number should be inferred from a different SKU.

Checkout is Interac e-Transfer to a Canadian address. Parcels move on Canada Post Xpresspost. The operational write-up is Canada laboratory procurement. Store the lyophilized vial sealed, the same day it arrives. Sold-out cards stay visible and cannot be added to the cart. Research-use only. Not for human or veterinary use.